Avoid “driver download” sites (e.g., driver-fixer.com, softonic). They repackage the same free driver with adware. Stick to Alesis/InMusic direct.
This often happens after a Windows update overwrites the driver. Go to Device Manager → Universal Serial Bus devices → Alesis Q49 → Update Driver → Browse my computer → Let me pick → Select Alesis USB MIDI Driver 4.1.0 . alesis q49 driver download high quality 2021
The Alesis Q49 draws power via USB. Modern computers (post-2021) utilize USB 3.0 and USB-C ports which may negotiate power differently than older USB 2.0 ports. Avoid “driver download” sites (e