To run actual NI Multisim, you need a full Windows x86 environment. You have two options: local VM (if you have a high-end Chromebook) or cloud VM.
Seamless Integration and Sharing: Multisim Live allows users to save designs to their NI account. This is particularly useful for students who may start a project on a school Chromebook and finish it on a home device. Projects can also be exported to the desktop version for advanced PCB layout and professional manufacturing. Educational Advantages multisim for chromebook
Stick with Multisim Live for 90% of use cases. It’s built by the same team and handles the transition from "learning" to "doing" very well on ChromeOS. To run actual NI Multisim, you need a