| Feature | Illumina (e.g., NovaSeq) | ONT MinION Mk1B | | :--- | :--- | :--- | | | Sequencing by Synthesis (Optical) | Nanopore (Electrical) | | Portability | Room-sized machine (tons) | Pocket-sized (100g) | | Read Length | Short reads (150-300 bp) | Ultra-long reads (up to 4 Mb+) | | Accuracy | >99.9% (High Q scores) | ~98-99% (Rapidly improving) | | Infrastructure | Requires specialized facility | Runs on a standard laptop | | Start-up Cost | Millions of USD | ~$1,000 (Device itself) |
: Powered by a 1GHz ARM Cortex A8 processor with 4GB of flash memory. 3. Alternative: Portable Power Sequencers (e.g., DPU414) portable sequencher 414
: While it is software, it can be made "portable" for field or multi-office use through a Hardware Key (USB dongle) . This allows a scientist to run the full software on any computer where the key is plugged in. | Feature | Illumina (e
: Handles both traditional Sanger sequencing and Next-Generation Sequencing (NGS) data. This allows a scientist to run the full