A proper, unmodified NTSC v1.02 ISO should have the following MD5 hash:
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To play your ISO on a real Wii or Wii U (with HDMI via Wii U). A proper, unmodified NTSC v1
To play online (via Slippi) or to use popular mods like UnclePunch, you specifically need an unmodified NTSC v1.02 ISO (the North American "rev 2" version). Verification: How to identify a true 1.02 ISO melee iso ntsc 102 install